4-Aminopyridine Chemical Properties,Uses,Production
Dalfampridine (also referred to as 4-AP) is the first drug approved by
the FDA to improve walking in patients with multiple sclerosis (MS).
Dalfampridine is a voltage-gated potassium channel blocker that readily
penetrates the CNS and increases the conduction and duration of action
potential across nerve fibers resulting in enhanced functionality as
observed in the walking speed of MS patients.
safety perspective, seizure was the most important adverse event from
various dalfampridine clinical trials. Therefore, dalfampridine is contraindicated
in patients with a history of seizures. Since dalfampridine is
primarily excreted by the kidney as unchanged drug, it is also contraindicated
in patients with moderate to severe renal impairment. Assessing
the overall benefit–risk profile from various clinical trials, the FDA
approved dalfampridine (daily oral dose of 10 mg, b.i.d.) to improve
walking in MS patients with existing gait impairment.
WHITE TO SLIGHTLY YELLOW FINE CRYSTALLINE POWDER
4-aminopyridine is a white crystalline solid that contains about 98% active ingredient. It is soluble in water and slightly soluble in benzene and ether. 4-Aminopyridine formulations are classifi ed by the US Environmental Protection Agency (US EPA) as restricted
use pesticides (RUPs) and therefore should be purchased and used only by certifi ed and
trained workers and applicators. Avitrol is available as grain baits or as a powder concentrate. It is one of the most prominent avicides. It is registered with the EPA for use against
red-winged blackbirds, blackbirds in agricultural fi elds, grackles, pigeons, and sparrows
around public buildings, and various birds around livestock feeding pens. Avitrol repels
birds by poisoning a few members of a fl ock, causing them to become hyperactive.
4-Aminopyridine is white to tan or brown crystalline material. Odorless.
Rush University Medical Center (United States)
Dalfampridine is used in characterizing subtypes of potassium channel, and has also been used to manage some of the symptoms of multiple sclerosis, and is indicated for symptomatic improvement of walking in adults with several variations of the disease. Dalfampridine is a precursor to the drug Pinacidil.
ChEBI: An aromatic amine that is pyridine bearing a single amino substituent at position 4. An orphan drug in the US, it is used to improve walking in adults with multiple sclerosis.
White crystalline material with no odor. Used as an avicide, an intermediate and as a fixer for some textile dyes.
4-Aminopyridine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Material may be fatal if inhaled, swallowed or absorbed through skin. Contact may cause burns to skin and eyes. Material affects neural transmission. In sufficient concentrations, material may cause metabolic acidosis, respiratory arrest, and cardiac arrhythmias.
4-Aminopyridine, a pyridine compound, is an extremely effective bird poison. In agriculture, 4-AP is used as an extremely effective bird poison sold under the brand name Avitrol.
It is highly toxic to all mammals including humans if dosages are exceeded, and as an
experimental drug, the recommended dose data is unavailable. 4-Aminopyridine blocks
Material may produce irritating or poisonous gases in fire. Runoff from fire control water may give off irritating or poisonous gases.
Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: hallucinations and vomiting. When heated to decomposition it emits toxic fumes of NOx,.
Used as a chemical intermediate in pharmaceuticals; as an agricultural chemical for field crops; and as a bird repellent and poison
UN2671 Aminopyridines, Hazard Class: 6.1; Labels: 6.1-Poisonous materials
Crystallise the aminopyridine from *benzene/EtOH, then recrystallise it twice from water, then crush and dry it for 4hours at 105o [Bates & Hetzer J Res Nat Bur Stand 64A 427 1960]. It has also been crystallised from EtOH, *benzene, *benzene/pet ether, toluene and sublimes in a vacuum. [Beilstein 22/9 V 106.]
Sodium nitrite, strong oxidizers. Avoid contact with acid anhydrides, acid chlorides; and strong acids.
Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposalIncineration with nitrogen oxides removal from effluent gas.
4-Aminopyridine Preparation Products And Raw materials