Butylated Hydroxytoluene Properties
- Melting point:
- 69-73 °C(lit.)
- Boiling point:
- 265 °C(lit.)
- vapor density
- 7.6 (vs air)
- vapor pressure
- <0.01 mm Hg ( 20 °C)
- refractive index
- Flash point:
- 127 °C
- storage temp.
- methanol: 0.1 g/mL, clear, colorless
- pKa 14(H2O t = 25 c = 0.002 to 0.01) (Uncertain)
- Water Solubility
- Stable, but light-sensitive. Incompatible with acid chlorides, acid anhydrides, brass, copper, copper alloys, steel, bases, oxidizing agents. Combustible.
- CAS DataBase Reference
- 128-37-0(CAS DataBase Reference)
- NIST Chemistry Reference
- Butylated hydroxytoluene(128-37-0)
- EPA Substance Registry System
- Phenol, 2,6-bis(1,1-dimethylethyl)- 4-methyl-(128-37-0)
- Risk and Safety Statements
- Hazard and Precautionary Statements (GHS)
|Autoignition Temperature||878 °F|
|Hazardous Substances Data||128-37-0(Hazardous Substances Data)|
|Toxicity||LD50 orally in mice: 1040 mg/kg (McOmie)|
|Health||0||Poses no health hazard, no precautions necessary and would offer no hazard beyond that of ordinary combustible materials|
|Flammability||1||Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia)|
|Instability||0||Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2)|
浙江体彩20选5单期走势图 www.yxnqz.tw (NFPA, 2010)
Butylated Hydroxytoluene price More Price(27)
|Manufacturer||Product number||Product description||CAS number||Packaging||Price||Updated||Buy|
|Sigma-Aldrich||03762||2,6-Di-tert-butyl-4-methylphenol tested according to Ph.Eur.||128-37-0||500g||$81.3||2018-11-13||Buy|
|Sigma-Aldrich||1082708||Butylated hydroxytoluene United States Pharmacopeia (USP) Reference Standard||128-37-0||500mg||$401||2018-11-13||Buy|
|TCI Chemical||D0228||2,6-Di-tert-butyl-p-cresol >99.0%(GC)||128-37-0||25g||$17||2018-11-22||Buy|
|TCI Chemical||D0228||2,6-Di-tert-butyl-p-cresol >99.0%(GC)||128-37-0||500g||$33||2018-11-22||Buy|
|Alfa Aesar||A16863||2,6-Di-tert-butyl-4-methylphenol, 99%||128-37-0||250g||$24.2||2018-11-13||Buy|
Butylated Hydroxytoluene Chemical Properties,Uses,Production
Chemical Propertieswhite crystalline solid
Chemical PropertiesBHT is a white to pale yellow crystalline solid or powder.
Chemical PropertiesButylated hydroxytoluene occurs as a white or pale yellow crystalline solid or powder with a faint characteristic phenolic odor.
Chemical PropertiesBHA and BHT (butylated hydroxytoluene) are monohydric phenolic antioxidants that, prior to their introduction and acceptance in the food industry, were used to protect petroleum against oxidative degumming. BHT has a very faint, musty, occasional cresylictype odor. BHA and BHT are extensively used in foods as antioxidants. Most fats, oils and fat-containing foods are naturally susceptible to rapid rancification and other oxidative reactions that produce compounds having objectionable taste and odor, making foods containing them unpalatable. Lipid oxidation is autocatalytic and proceeds as a complex of chain reactions, the nature and speed of which vary with the substrate, temperature, light, availability of oxygen and presence or absence of oxidation catalysts. Antioxidants like BHT act as “chain breaks” in the autooxidation processes under the usual conditions of processing, storage and use of fat-containing foods (Burdock, 1997).
OccurrenceNot reported found naturally.
UsesBecause they prevent rancidity, antioxidants are of great interest to the food industry. For example, butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA), and EDTA are frequently used to preserve various foods, such as cheese or fried products. Butylated hydroxytoluene is a powerful inhibitor of lipid peroxidation, yet large doses of it can induce oxidative DNA damage and cancer development in the rat forestomach.
UsesBHT is also known as butylated hydroxy toluene. It is an anti-oxidant that also has preservative and masking capabilities.
UsesButylated Hydroxytoluene (BHT) is an antioxidant that functions similarly to butylated hydroxyanisole (BHA) but is less stable at high temperatures. It is also termed 2,6-di-tert-butyl-para-cresol. See Butylated Hydroxyanisole.
UsesAntioxidant 264 as general antioxidants is used widely in polymer materials, petroleum products and food processing industries. Antioxidant 264 is commonly used rubber antioxidant, heat, oxygen aging have some protective effect, but also can inhibit copper harm. This product does not change color, not pollution. Antioxidants 264 high solubility in oil, no precipitation, less volatile, non-toxic and non-corrosive.
UsesAntioxidant for food, animal feed, petroleum products, synthetic rubbers, plastics, animal and vegetable oils, soaps. Antiskinning agent in paints and inks.
DefinitionChEBI: A member of the class of phenols that is 4-methylphenol substituted by tert-butyl groups at positions 2 and 6.
PreparationBHT is produced commercially by the alkylation of para-cresol with isobutylene. BHT is also produced by several western European manufacturers, production/processing plants in Germany, France, the Netherlands, United Kingdom and Spain.
Production MethodsPrepared by the reaction of p-cresol with isobutene.
General DescriptionWhite crystalline solid.
Air & Water ReactionsInsoluble in water.
Reactivity ProfilePhenols, such as 2,6-Di-tert-butyl-4-methylphenol, do not behave as organic alcohols, as one might guess from the presence of a hydroxyl (-OH) group in their structure. Instead, they react as weak organic acids. Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has Ka = 1.3 x 10^[-10]). These materials are incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction between phenols and bases. Such heating may initiate polymerization of the organic compound. Phenols are sulfonated very readily (for example, by concentrated sulfuric acid at room temperature). The reactions generate heat. Phenols are also nitrated very rapidly, even by dilute nitric acid. Nitrated phenols often explode when heated. Many of them form metal salts that tend toward detonation by rather mild shock. May react with oxidizing materials.
Fire Hazard2,6-Di-tert-butyl-4-methylphenol is combustible.
Pharmaceutical ApplicationsButylated hydroxytoluene is used as an antioxidant in cosmetics, foods, and pharmaceuticals. It is mainly used to delay or prevent the oxidative rancidity of fats and oils and to prevent loss of activity of oil-soluble vitamins.
Butylated hydroxytoluene is also used at 0.5–1.0% w/w concentration in natural or synthetic rubber to provide enhanced color stability.
Butylated hydroxytoluene has some antiviral activity and has been used therapeutically to treat herpes simplex labialis.
Contact allergensThis antioxidant is contained in food, adhesive glues, industrial oils, and greases, including cutting fluids. Sensitization seems very rare.
SafetyButylated hydroxytoluene is readily absorbed from the gastrointestinal tract and is metabolized and excreted in the urine mainly as glucuronide conjugates of oxidation products. Although there have been some isolated reports of adverse skin reactions, butylated hydroxytoluene is generally regarded as nonirritant and nonsensitizing at the levels employed as an antioxidant.
The WHO has set a temporary estimated acceptable daily intake for butylated hydroxytoluene at up to 125 μg/kg body-weight.
Ingestion of 4 g of butylated hydroxytoluene, although causing severe nausea and vomiting, has been reported to be nonfatal.
LD50 (guinea pig, oral): 10.7 g/kg
LD50 (mouse, IP): 0.14 g/kg
LD50 (mouse, IV): 0.18 g/kg
LD50 (mouse, oral): 0.65 g/kg
LD50 (rat, oral): 0.89 g/kg
Potential ExposureDBPC is used as a food and feed additive, flavor, and packaging material; as an antioxidant in human foods and animal feeds. It is also used as an antioxidant to sta- bilize petroleum fuels, rubber and vinyl plastics.
Enzyme inhibitorThis radical scavenger and widely used antioxidant (FW = 220.36 g/mol; CAS 128-37-0; IUPAC Name: 2,6-bis(1,1-dimethylethyl)-4-methylphenol; Symbol: BHT; Soluble in most oils) inhibits food spoilage by terminating free radical reactions through the conversion of peroxy radicals (R–O2 ?) to hydroperoxides (R–OOH). This is accomplished by donating a hydrogen atom (Reaction: R–O2 ? + BHT–OH → ROOH + BHT–O?). where R is alkyl or aryl, and where BHT–OH indicates the hydroxyl group of butylated hydroxytoluene. The key to BHT’s effectiveness is the formation of a highly stabilized oxygen free radical that is poorly reactive due to steric contraints.
First aidMove victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respira- tion with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with run- ning water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin. Keep victim warm and quiet. Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. Medical obser- vation is recommended for 24 to 48 hours after breathing overexposure, as pulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized para- medic may consider administering a drug or other inhala- tion therapy.
storageExposure to light, moisture, and heat causes discoloration and a loss of activity. Butylated hydroxytoluene should be stored in a wellclosed container, protected from light, in a cool, dry place.
ShippingUN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
Purification MethodsDissolve BHT in n-hexane at room temperature, then cool with rapid stirring, to -60o. The precipitate is separated, redissolved in hexane, and the process is repeated until the mother liquor is no longer coloured. The final product is stored under N2 at 0o [Blanchard J Am Chem Soc 82 2014 1960]. It has also been recrystallised from EtOH, MeOH, *benzene, n-hexane, methylcyclohexane or pet ether (b 60-80o), and is dried in a vacuum. [Beilstein 6 IV 3511.]
IncompatibilitiesButylated hydroxytoluene is phenolic and undergoes reactions characteristic of phenols. It is incompatible with strong oxidizing agents such as peroxides and permanganates. Contact with oxidizing agents may cause spontaneous combustion. Iron salts cause discoloration with loss of activity. Heating with catalytic amounts of acids causes rapid decomposition with the release of the flammable gas isobutene.
IncompatibilitiesContact with oxidizers may cause fire and explosion hazard.
Regulatory StatusGRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (IM and IV injections, nasal sprays, oral capsules and tablets, rectal, topical, and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Butylated Hydroxytoluene Preparation Products And Raw materials
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View Lastest Price from Butylated Hydroxytoluene manufacturers
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Butylated Hydroxytoluene 2,6-Di-tert-butyl-4-methylphenol
|US $1.00 / kg||1kg||99%||High quality Factory||Chemwill Asia Co.,Ltd.|
Butylated hydroxytoluene Manufacturer; In stock GMP Factory
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Butylated Hydroxytoluene Spectrum
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- Butylated hydroxytoluene,Granular
- 264 2,6-Bis(1,1-dimethylethyl)-4-methylphenol
- 2,6-Di-tert-butyl-4-methylphenol ,98.5%
- 2,6-Di-tert-butyl-4-methylphenol,2,6-Di-tert-butyl-p-cresol, BHT, Butylated hydroxytoluene, Butylhydroxytoluene, Butylhydroxytoluenum, DBPC
- 2,6-Di-tert-butyl-4-methylphenol, synthesis grade